Recombinant:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Variant Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Luciferase:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Reporter Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Expressing:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Plasmid Preparation:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Translocation Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Quantitative RT-PCR:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Binding Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Activation Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Construct:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Reporter Gene Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Mutagenesis:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Control:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Transfection:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Ligand Binding Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
MANN-WHITNEY:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
Whisker Assay:Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model
Article Snippet: Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHH medium 2 h later when the cells attached to the plate surface. .. T
Article Title: The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model.
Article Snippet: human hepatocytes (PHH) and 3D spheroids of PHH 2D primary human hepatocyte culture. .. Primary human hepatocytes (PHHs, donor OFA, BioIVT, Westbury, New York, USA) were seeded onto rat tail collagen type I-coated 24-well plate (Corning, New York, USA) (350,000 cells per well) in PHH medium as described60 with 10% fetal bovine serum (FBS, HyClone), which was exchanged for FBS-free PHHmedium 2 h later when the cells attached to the plate surface. .. The next day, 2D PHH cells were exposed to either MI-883 (5 μM), SPA70 (10μM), CITCO (1μM),
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